中文摘要

目的：本课题主要通过陈颜主任医师整合孙定隆副教授的经验方苦薤香汤治疗湿热型急性非感染性腹泻的经验，通过随机对照临床试验，观察经验方苦薤香汤对急性非感染性腹泻病湿热型的临床疗效。

方法：选取符合急性非感染性腹泻病人70例，病例均来自于州中医药大学第一附属医院消化专科门诊、病房和急诊科肠道门诊。采用随机分组的方法，分为治疗和对照组两组，两组各35例。因未按规定疗程治疗、依从性差，疗程中自行退出、失访、因疗效缺乏而自行退出等原因退出者共10例，治疗组5例，对照组5例，故最后纳入研究并计入疗效统计共60例，i其中治疗组予苦薤香汤治疗，对照组予蒙脱石散治疗，3天为一疗程，治疗一疗程后，对两组患者采用症状积分评价对其治疗前后进行疗效评价；拟采用SPSS21.0进行资料分析，观察两组之间治疗后的差异性，综合评价苦薤香汤治疗急性非感染性腹泻疗效。

结果：1、从总体疗效来看，苦薤香汤组和西药组均能有效的治疗急性非感染性腹泻。苦薤香汤组和西医组的治疗总有效率分别是93.3%，90%。从总体疗效来看，治疗组疗效较对照组好。差异有统计学意义(P＜0.05)。

两组治疗后症候总积分均降低，差异有统计学意义(P＜0.05)，但是治疗组的总分低于对照组，表明治疗组在降低中医证候积分上的效果比对照组更佳。

两组治疗后的主症积分较治疗前明显降低，差异具有统计学意义(P＜0.05)，治疗组在泻下急迫或泻下不爽、肛门灼热、舌苔黄腻和主症总分等方面的治疗疗效更优于对照组。在大便色黄秽臭指标上差异无统计学意义，结果显示两组在改善便色黄秽臭上效果相当。

两组治疗后次要症状积分都显著降低，差异有统计学意义（P<0.05），治疗组在腹痛、脉濡数或滑数和次症总分的效果好于对照组，两组在烦热口渴、小便短黄指标上差异无统计学意义，说明两组在改善烦热口渴、小便短黄指标上效果相当。

关键词：急性非感染性腹泻；临床观察；苦薤香汤

Abstract

Objective: This topic is mainly based on the experience of Chief Physician Chen Yan integrating Associate Professor Sun Dinglong’s experience in the treatment of damp-heat acute non-infectious diarrhea with Kuxiexiang Decoction,and through randomized controlled clinical trials to observe the experience of Kuxiexiang Decoction on acute non-infectious diarrhea. The clinical effect of damp-heat type.

Methods: Seventy patients with acute non-infectious diarrhea were selected.The cases were all from the outpatient department of gastroenterology,the ward and the intestinal outpatient department of the emergency department of the First Affiliated Hospital of State University of Traditional Chinese Medicine. Using the method of random grouping,they were divided into two groups of treatment and control group, with 35 cases in each group. A total of 10 patients who withdrew due to failure to follow the prescribed course of treatment,poor compliance, withdrawal during the course of treatment, loss to follow-up,and withdrawal due to lack of efficacy, a total of 10 cases,5 cases in the treatment group, 5 cases in the control group,so they were finally included in the study and included in the efficacy A total of 60 cases were counted, i of which the treatment group was treated with Kuxiexiang Decoction, and the control group was treated with Montmorillonite powder. A course of treatment was 3 days.After a course of treatment,the two groups of patients were evaluated by symptom score before and after treatment. Evaluation: It is planned to use SPSS21.0 for data analysis, observe the differences between the two groups after treatment, and comprehensively evaluate the curative effect of Kuxiexiang Decoction in the treatment of acute non-infectious diarrhea.

Results: 1.From the overall effect,both the Kuxiexiang Decoction Group and the Western Medicine Group can effectively treat acute non-infectious diarrhea. The total effective rates of Kuxiexiang Decoction group and Western medicine group were 93.3% and 90%, respectively.In terms of overall efficacy, the treatment group has better efficacy than the control group.The difference was statistically significant (P<0.05).

2.The total scores of symptoms of the two groups were reduced aftertreatment, and the difference was statistically significant (P<0.05), but the total score of the treatment group was lower than that of the control group, indicating that the treatment group was more effectivein reducing the TCM syndrome scores than the control group good.