中文摘要

目的：应用统计学与数据挖掘的方法，探讨陈宝贵教授以温中愈疡散寒法治疗虚寒型消化性溃疡（Peptic ulcer，PU）的组方用药规律及配伍特点，经过陈宝贵教授精心指导，得到核心处方愈疡汤（愈疡颗粒）。再通过临床研究评价愈疡颗粒联合雷贝拉唑肠溶胶囊药组对比雷贝拉唑肠溶胶囊药组治疗虚寒型PU的临床疗效优势所在，并且评价愈疡颗粒治疗PU的有效性及安全性，为中西医结合治疗PU提供可行的治疗方案。

方法：

关键词：消化性溃疡；虚寒型；数据挖掘；临床观察；愈疡颗粒

ABSTRACT

Objective: Application of statistical methods and data mining to explore professorBaogui to warm Yuyang cold treatment of peptic ulcer Deficiency Type (Pepticulcer,PU) the prescription drug law and compatibility characteristics,after careful guidance of Professor Baogui, get The core prescription Yuyang Tang (Yuyang granule). Clinical Evaluation through the combined particles Ulcer rabeprazole enteric-coated capsulesof drug administration group Bileibeila azole group enteric-coated capsules drugs group medicine group Deficiency type clinical efficacy advantage where PU and PU evaluated Ulcer Treated the efficacy and safety, provide a viable treatment options for Integrative Medicine PU.

Methods:

1.Data Mining: Screening from January 2016 to December 2016, Chen Baogui,the diagnosis of the disease is 100 cases of the diseased PU, using MicrosoftExcel, SPSSModeler18.0, SPS20.0 and other statistical software for data mining,analysis Treat Professor of Treatment of Frequent Cold PUs and Its Compatibility and Its Compatibility, and obtains the core preliminary healing soup under the guidance of Professor Chen. 2.Clinical observation: 80 patients who were included in Tianjin Wuqing District Hospital of Traditional Chinese Medicine in accordance with the inclusion of standard PUs, 40 cases of observation group, 40 cases of control group. The control group was treated with the Raziprazole intestinal solochene drug group and the Ruiba Piece,and the observation group was treated with healing particles on the basis of the control group. The two groups of treatment were 4 weeks.Observing the symptoms of traditional Chinese medicine before and after the treatment of two groups, the gastroscope examination, and statistical analysis of SPS20.0 for the observed and statistical data.

Results:

1.Data Mining Results: Professor Chen Baogui treats the medicinal properties ofthe deficiency of the cold PU drugs with temperature, flat, salt, salty,bitter, returning to the spleen, stomach, lung, heart, liver Most of the kidney. By analyzing Professor Chen to treat the drug and compatibility characteristics of the vanish PU, at the guidance of Professor Chen, the best drug composition,ratio and dose of the core square: ginger is 12g, dried ginger 9g,fragrant 10g, Yanhusuo 10g, Haiji 20, white and 6g,three or seven powder 3g, party ginseng 10g, licorice 6g, shell 6g - named hymerce soup, its particulate preparation is hyrmory particles.

2.Clinical research results: Comparison of Chinese medicine certificate:After treatment, the total efficiency of TCM syndrome efficacy is 94.3%, and the total effective rate of the control group is 76.3%.The observation team is generally better than the control group (P<0.05).TCM clinical symptoms Comparison: After treatment,both groups can effectively improve the stomach pain, hi-hgy, fast abdomen, have a pain, fatigue, cold limbs, less cold, tall food, stool, etc. Symptom (P<0.05).On the improvement of stool,there was no significant difference in the efficacy of the two groups (P>0.05).In the stomach hurt, the warmth is hurt, the blood is heavy,the pain is reduced, the fatigue of the limbs, the cold and cold limbs, the natal food, etc., there is a significant difference in the two groups (P<0.05), The observation group was significantly better than the control group.No adverse reactions occurred during the experiment.Comparison of ulceration effects under gastric lens: After treatment, the observation group of gastroscopic ulceration is 94.3%, and the effective rate of ulcer under the gastric mirror under the control group is 84.2%, and the effect is not statistically significant difference between the two groups of gastroscope (P>0.05), the effect of ulceration is quite.

Conclusion: Chen Baogui, who is based on data mining,treats the core square hymerce particles of the deficiency of the cold PU combined with the Razipole sausage capsule, which can effectively relieve the clinical symptoms of patients, improve the spleen and stomach deficiency Cold Chinese Medical Signs. And the test procedure did not have adverse reactions,with safety and reliable efficacy, it is worth clinically promotion and use.

Key words: digestive ulcer; virtual cold type;data mining; clinical observation; hyrmory particles